- Distance from chip determines minimum latency
- Speed of light is a constant
- Impact of bus frequencies
- IDE (66,100,133 Hz)
- PCI, PCI-X (66,100,133 Hz)
- PCI Express (1Ghz to 12Ghz)
- Impact of bus bandwidths
- PCI (32/64 bit/cycle, 133MB/s)
- PCI Express (x16 8.0GB/s)
Here's a link from Intel showing a machine architecture with signal bandwidths: Intel diagram